Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016

نویسندگان

  • Tatiana Baranovich
  • Phengta Vongphrachanh
  • Pakapak Ketmayoon
  • Thongchanh Sisouk
  • Khampheng Chomlasack
  • Viengphone Khanthamaly
  • Ha Thuy Nguyen
  • Vasiliy P. Mishin
  • Henju Marjuki
  • John R. Barnes
  • Rebecca J. Garten
  • James Stevens
  • David E. Wentworth
  • Larisa V. Gubareva
چکیده

In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation.

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عنوان ژورنال:

دوره 23  شماره 

صفحات  -

تاریخ انتشار 2017